Radiation therapy oncology group rtog 0618 a phase ii trial of stereotactic body radiation therapy sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer study chairs 2409 principal investigatorradiation oncologyigrt robert d. A randomized phase iii clinical trial evaluating postmastectomy chestwall and regional nodal xrt and postlumpectomy regional nodal xrt in patients with positive axillary nodes before neoadjuvant chemotherapy who convert to pathologically negative axillary nodes after neoadjuvant chemotherapy. Two prospective, randomized, phase 2 trials investigated the safety and efficacy of sfsbrt. Survival and toxicities of imrt based on the rtog protocols. Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Surgery versus stereotactic body radiation therapy for stage.
May 01, 20 rtog 0418 specified that the pelvic lymphatics were contoured according to rtog guidelines. Patients with the following pathology findings may be treated with pelvic radiation with or without weekly cisplatin at the treating physicians discretion. The imagebased deep learning framework proposed herein is the first opportunity to use medical images to individualise radiotherapy dose. Rtog manuscripts and abstracts submitted for publication. Rtog 0614 was a randomized trial of wbrt versus wbrt and memantine in patients with brain metastases and showed better cognitive function over time in the memantine group.
Radiation therapy oncology group rtog study 0915 compared 34 gy in a single fraction to 48 gy in 4 fractions, and the roswell park institute rpci study i 124407 compared 30 gy in a single fraction to 60 gy in 3 fractions. Radiation treatment planning with embedded dose escalation. No other use or reproduction is authorized by rtog nor does rtog assume. Rtog is funded by national cancer institute grant numbers. Minor deviations from rtog 08 compliance criteria while using mc algorithms are very common and were also reported in previous studies. Oct 21, 2016 angiogenesis, a hallmark of glioblastoma, can potentially be targeted by inhibiting the vegf pathway using bevacizumab, a humanized monoclonal antibody against vegfa. Angiogenesis, a hallmark of glioblastoma, can potentially be targeted by inhibiting the vegf pathway using bevacizumab, a humanized monoclonal antibody against vegfa. Starting october 1, 2010, all adverse events aes for rtog 0915 must be reported using ctcae version 4. This site will allow users to register a patient or enter case form data directly to a nrgrtog study twentyfour 24 hours a day, seven 7 days a week. Radiation therapy with or without cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Your doctor may recommend this study if you have a lowgrade primary brain cancer. Rtog 0915, amended amended rtog 0915, a randomized phase ii study comparing 2 stereotactic body radiation therapy sbrt schedules for medically inoperable patients with stage i peripheral nonsmall cell lung cancer amendment 2. Nov 29, 2017 stereotactic body radiation therapy sbrt has been proposed as a potential alternative to surgery for early lung cancer, although we lack wellpowered prospective randomized data comparing these treatments, and existing studies suffer from incomplete information on confounders that can bias results.
The need for central pathology tumor grading in prostate cancer using radiation therapy oncology group rtog 8531. Radiation therapy oncology group rtog study 0915 compared 34 gy in a single fraction to 48 gy in 4 fractions, and the roswell park institute rpci study i 124407 compared 30. A randomized phase 2 study comparing 2 stereotactic body radiation. The vaginal internal target volume was created with use of a full and empty bladder scan. Phase ii study of multiple daily fractionations in the. An imagebased deep learning framework for individualising. Our results signify a new roadmap for deep learningguided predictions and treatment guidance in the imagereplete and highly standardised. Radiation oncologyrtog trials wikibooks, open books for an. There has been one late grade 3 gi toxicity reported and only one acute grade 3 gastrointestinal toxicity.
Secondary analysis of rtog 9508, a phase 3 randomized trial. Calgb 30610 rtog 0538 limited small cell 45 gy bid 3 weeks 61. The effect of beam arrangements and the impact of non. Jan 07, 20 recently published results from the longterm followup of radiation therapy oncology group rtog trial 9802 demonstrated medically meaningful and statistically significant survival prolongation. Rtog 0233 cdr0000258303 ecogr0233 nci201101578 registry identifier.
Pelvic irradiation with concurrent chemotherapy versus. Rtog 0915 12gy x 4 vs 30gy x 1 showed equivalent control results 97% lc in both arms. Clinical trials system american college of radiology. Videtic and others published radiation therapy oncology group rtog protocol 0915. Please visit the rtog website for the latest trials and protocol information. Multicenter evaluation of dose conformity in stereotactic. Combination chemotherapy and radiation therapy withwithout. Longterm followup on nrg oncology rtog 0915 ncctg n0927. Consideration of dose limits for organs at risk of thoracic. Stereotactic body radiation therapy sbrt has been proposed as a potential alternative to surgery for early lung cancer, although we lack wellpowered prospective randomized data comparing these treatments, and existing studies suffer from incomplete information on confounders that can bias results.
The protocol specified a 7mm expansion on these volumes to generate a planning target volume ptv, and 50. It is intended to be used only in conjunction with institutionspecific irb approval for study entry. For rtog 8502, there were 32 patients alive at 9 months and 19 patients alive at 12 months available for evaluation of late toxicity. We are a leading protocol organizations within the national clinical trials network and we seek to improve the. The materials presented on this website illustrate the consensus reached among cooperative groups and disease site committees. Nrg oncology rtog 6 a randomized phase ii study of. Phase iii randomized study of concurrent chemotherapy and. This study was designed to determine the efficacy and safety of these regimens in the cooperative group setting. Grignon d, pajak t, hammond e, et al application of the gleason grading system.
The prescription isodoses for the plans were kept to between 59% and 90% as recommended by rtog 11 and ding et al. Rtog 0418 specified that the pelvic lymphatics were contoured according to rtog guidelines. Rtog and authors are not responsible for any use of these guidances by third parties. Paclitaxel and carboplatin weekly for 6 weeks followed by 2 cycles of consolidation. As of may 2001 ijrobp vol 51 no 3 suppl 2, 1468, 2001. Evaluation of acuros xb algorithm based on rtog 08. Here, we evaluated the comparative effectiveness of surgery and sbrt in lung cancer treatment. Rtog 0236 and rtog 0915 prospectively evaluated sbrt in medically inoperable patients. Rtog 0631 phase 23 study of image guided stereotactic. May 16, 2016 per treating physicians discretion, a choice of 2 chemotherapy regimens. Radiation therapy with or without cetuximab in treating. Ctrp clinical trial reporting program first posted. Rtog 0915 nrg oncology rtog 0915 ncctg n0927 a randomized phase ii study comparing 2 stereotactic body radiation therapy sbrt schedules for medically inoperable patients with stage i peripheral nonsmall cell lung cancer document history 3614 versionupdate date broadcast date amendment 4 march 6, 2014 march 19, 2014. Recently published results from the longterm followup of radiation therapy oncology group rtog trial 9802 demonstrated medically meaningful.
Threedimensional descriptions of the lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus are presented. If you would like to utilize this site to register a patient and have not been assigned a login name and password from nrgrtog headquarters, please access the password authorization form. This is an ascii program runs in a winterm or xterm window with a keyboard interface and commands, in windows a command prompt window and is invoked with the flag d followed by the directory where the rtog files are for the particular patient. Pmid 11702729 2001 rtog publications since 1996 ijrobp vol 51 no 3 suppl 2, 125145, 2001. The management of lung cancer american society for. Here, we evaluated the comparative effectiveness of surgery and sbrt in lung cancer.
Cisplatin and etoposide, every 4 weeks, for 2 cycles. Contouring atlases anorectal bladder atlas brachial plexus contouring atlas. Aug 11, 2009 radiation therapy with or without cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Radiation therapy oncology group rtog protocol 0915. The decision to add weekly cisplatin for these patients is at the treating physicians discretion. The radiation therapy oncology group has completed 2 trials rtog 0614 and 0933 aimed at reducing the toxicity of wbrt. Stereotactic body radiation therapy versus surgery for early. According to the most recent statistics released by the american cancer society, lung cancer will be the second most commonly diagnosed cancer in 20, with an estimation of 118,080 and 110,110 new cases in men and women, respectively. The rtog 0225 and rtog 0615 protocols for npc provided good treatment outcomes and acceptable rtrelated toxicities in patients from the nonendemic regions 12. Mild tightness of skin and itching may occur to promote hydrated skin, patient comfort and maintain skin integrity.73 293 1535 762 1073 230 823 1269 1003 1485 701 1605 388 1129 1006 1584 865 1260 388 222 1251 1615 731 677 1574 799 104 246 355 363 1470 1202 446 969 1235 1022 906 909 1115